this study aimed to investigate the effects of different doses of sulfadiazine on embryonic chicken pectoral muscles. in total, 100 fertile eggs were obtained and divided into five groups of control (no injection) and sulfadiazine injection at doses of 2, 10, 30, and 70 mg/kg. after hatching, pectoral muscle tissues were harvested from the newly hatched chickens for histopathological examinatio...

maternal smoking has been recognized as a common cause of low birth weight, preterm birth and the decrease of gestational age period. unfortunately, there is an increasing interest within public especially woman in iran in the tobacco products consumption. on the other hand, the deleterious effect of maternal smoking on human fetus in pregnancy period especially in the first trimester encourage...

in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decrea...

in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decreas...

Early life-stage bioassays have been used as an alternative to short-term adult toxicity tests since they are cost-effective. A single couple can produce hundreds or thousands of embryos and hence can be used as a simple high-throughput approach in toxicity studies. In the present study, zebrafish and sea urchin embryo bioassays were used to test the toxicity of four pharmaceuticals belonging t...

although the biokinetics, metabolism, and chemical toxicity of atorvastatin calcium are well known, until recently little attention was paid to the potential toxic effects of atorvastatin calcium on re-production and development in mammals. in recent years, it has been shown that atorvastatin calcium is a developmental toxicant when given orally or subcutaneously (sc) to mice. decreased fertili...

The dynamic interplay between toxicity pathways (oxidative stress, calcium disturbances, genetic damage) caused by nanoparticles and the repair mechanisms of inhibition cell division induction death is explored in zebrafish embryo cells.

UNLABELLED BACKGROUNDS Previous studies suggested that endocrine disruptors (ED) are toxic on preimplantation embryos and inhibit development of embryos in vitro culture. However, information about the toxicity of endocrine disruptors on preimplantation development of embryo in human reproductive environment is lacking. METHODS Bisphenol A (BPA) and Aroclor 1254 (polychlorinated biphenyls)...